ARISTADA Care Support resources

Learn more about ARISTADA Care Support services for your patients.

Enroll your eligible patients to get services like benefit verification, financial assistance, and transition of care services. There are 4 simple steps:

  • Download the Enrollment Form and type in your information on screen.
  • Print the completed form and obtain signature of patient or authorized designee.
  • Fax form to ARISTADA Care Support at 1-844-464-7171.
  • ARISTADA Care Support will contact your patient’s insurer and provide a summary of your patient’s benefits.

Enroll your patient in any care setting.

Online patient enrollment is also available with iAssist.

ARISTADA is covered by a majority of healthcare plans, including Medicare, Medicaid, and most commercial plans.1 See if your patients are covered.

Reference: 1. Data on file. Alkermes, Inc.

The ARISTADA Provider Network is a voluntary network of healthcare providers who are willing to accept patients and can administer an intramuscular injection of an Alkermes FDA-approved product, such as ARISTADA, to appropriate patients.

You can also join the ARISTADA Provider Network.

ARISTADA Care Support can assist you during the prior authorization (PA) process. Download this checklist for requesting prior authorization for ARISTADA to help ensure your request is accurate.

This editable template supports your prior authorization/formulary exception requests for ARISTADA. offers free electronic prior authorization (ePA) services and ability to:

  • Find, complete, and submit prior authorizations to any payer
  • Receive electronic determinations
  • Create prior authorization renewals

iAssist is an e-prescribing and electronic prior authorization technology platform that is designed to support patient access to specialty therapies. ARISTADA is available to order on iAssist, which allows for the following:

  • Electronic enrollment into ARISTADA Care Support services
  • Verification of patient health plan eligibility information in real time
  • Electronic access and completion of various health plan prior authorization forms (if applicable)
  • Attachment and submission of electronic medical records (EMRs) and electronic prescriptions (eRx) via Surescripts

If you have a claim denied, ARISTADA Care Support can help you obtain information regarding the denial of coverage and provide appeal requirements. Download this checklist for appealing a claim denial for ARISTADA to help ensure your appeal is accurate.

This editable template was developed to help patients request an appeal of a denied insurance claim for ARISTADA.

ARISTADA is coded differently than oral aripiprazole and ARISTADA has a unique J-Code. See the list of billing codes and additional information in this compact guide.

Reimbursement for ARISTADA differs from oral therapies dispensed to patients for self-administration. Place of service, type of payer, and benefit category are the 3 main considerations that affect coverage and reimbursement for treatment with ARISTADA. This comprehensive guide will help you understand ARISTADA reimbursement.

For provider entities wanting to buy and bill ARISTADA, a handy coding sheet is available for reference and download.

ARISTADA is available from a variety of pharmaceutical wholesalers. See the comprehensive list here.

Samples are available for your patients with schizophrenia. Just request a visit from an ARISTADA representative.

You can get ARISTADA from Besse Medical pharmaceutical supplier. Direct-purchase discount is available to eligible providers through the Alkermes provider distribution partner, Besse Medical.*

*Contact Besse Medical regarding eligibility for program pricing.

Get pricing information for ARISTADA, including the ARISTADA Provider Pricing Program managed by Besse Medical.

See ordering information for ARISTADA prescribers.

Access to ARISTADA for your hospitalized patients with schizophrenia.

Eligible hospital pharmacies may request free trial units of ARISTADA, and orders ship directly to your hospital.* Hospitalized patients with schizophrenia may receive up to 2 free trial units of ARISTADA per calendar year, subject to quantity limits. There is no requirement for subsequent use of ARISTADA for any patient receiving a free trial unit through this program.

*Shipments will not be processed on holidays or pending inclement weather. These factors may result in a delay in shipment.

A comprehensive review of product information to assist hospital pharmacists, physicians, and executives in making formulary decisions.

For patients transitioning from hospital to outpatient care, be sure to select the Transition of Care Support Program on the enrollment form. A prescription is not required for transition support. Through the program, ARISTADA Care Support nurse coordinators can:

  • Contact both inpatient and outpatient staff to assist the patient in transitioning from the hospital to the outpatient setting for their ARISTADA treatment
  • Schedule appointments and provide appointment confirmations and reminders, if needed
  • If requested, identify potential sites that can administer ARISTADA for follow-up care

Informative brochure about treating schizophrenia with ARISTADA.

Information to help with navigating the coverage landscape.

Complete this treatment reminder card and provide it to patients when they are leaving the hospital. It may help provide important information to their outpatient healthcare professional.

Learn more about ARISTADA
For more information about ARISTADA, visit our product website.


ARISTADA® (aripiprazole lauroxil) is indicated for the treatment of schizophrenia.

Important Safety Information

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. ARISTADA is not approved for the treatment of patients with dementia-related psychosis.

Contraindication: Known hypersensitivity reaction to aripiprazole. Reactions have ranged from pruritus/urticaria to anaphylaxis.

Cerebrovascular Adverse Reactions, Including Stroke: Increased incidence of cerebrovascular adverse reactions (e.g., stroke, transient ischemic attack), including fatalities, have been reported in placebo-controlled trials of elderly patients with dementia-related psychosis treated with risperidone, aripiprazole, and olanzapine. ARISTADA is not approved for the treatment of patients with dementia-related psychosis.

Neuroleptic Malignant Syndrome (NMS): A potentially fatal symptom complex sometimes referred to as NMS may occur with administration of antipsychotic drugs, including ARISTADA. Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia). Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure. The management of NMS should include: 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy; 2) intensive symptomatic treatment and medical monitoring; and 3) treatment of any concomitant serious medical problems for which specific treatments are available.

Tardive Dyskinesia (TD): The risk of developing TD (a syndrome of abnormal, involuntary movements) and the potential for it to become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic increase. The syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. Prescribing should be consistent with the need to minimize TD. Discontinue ARISTADA if clinically appropriate. TD may remit, partially or completely, if antipsychotic treatment is withdrawn.

Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that include:

  • Hyperglycemia/Diabetes Mellitus: Hyperglycemia, in some cases extreme and associated with ketoacidosis, coma, or death, has been reported in patients treated with atypical antipsychotics. There have been reports of hyperglycemia in patients treated with oral aripiprazole. Patients with diabetes should be regularly monitored for worsening of glucose control; those with risk factors for diabetes should undergo baseline and periodic fasting blood glucose testing. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia, including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia should also undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients require continuation of antidiabetic treatment despite discontinuation of the suspect drug.
  • Dyslipidemia: Undesirable alterations in lipids have been observed in patients treated with atypical antipsychotics.
  • Weight Gain: Weight gain has been observed with atypical antipsychotic use. Clinical monitoring of weight is recommended.

Pathological Gambling and Other Compulsive Behaviors: Compulsive or uncontrollable urges to gamble have been reported with use of aripiprazole. Other compulsive urges less frequently reported include sexual urges, shopping, binge eating and other impulsive or compulsive behaviors which may result in harm for the patient and others if not recognized. Closely monitor patients and consider dose reduction or stopping ARISTADA if a patient develops such urges.

Orthostatic Hypotension: Aripiprazole may cause orthostatic hypotension which can be associated with dizziness, lightheadedness, and tachycardia. Monitor heart rate and blood pressure, and warn patients with known cardiovascular or cerebrovascular disease and risk of dehydration and syncope.

Falls: Antipsychotics including ARISTADA may cause somnolence, postural hypotension, or motor and sensory instability, which may lead to falls and subsequent injury. Upon initiating treatment and recurrently, complete fall risk assessments as appropriate.

Leukopenia, Neutropenia, and Agranulocytosis: Leukopenia, neutropenia, and agranulocytosis have been reported. Patients with a history of clinically significant low white blood cell count (WBC)/absolute neutrophil count (ANC) and history of drug-induced leukopenia/neutropenia should have frequent complete blood count (CBC) during the first few months of receiving ARISTADA. Consider discontinuation of ARISTADA at the first sign of a clinically significant decline in WBC count in the absence of other causative factors. Monitor patients with clinically significant neutropenia for fever or other symptoms or signs of infection and treat promptly if such symptoms or signs occur. Discontinue ARISTADA in patients with severe neutropenia (absolute neutrophil count <1000/mm3) and follow their WBC until recovery.

Seizures: ARISTADA should be used with caution in patients with a history of seizures or with conditions that lower the seizure threshold.

Potential for Cognitive and Motor Impairment: ARISTADA may impair judgment, thinking, or motor skills. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are certain ARISTADA does not affect them adversely.

Body Temperature Regulation: Disruption of the body’s ability to reduce core body temperature has been attributed to antipsychotic agents. Advise patients regarding appropriate care in avoiding overheating and dehydration. Appropriate care is advised for patients who may exercise strenuously, may be exposed to extreme heat, receive concomitant medication with anticholinergic activity, or are subject to dehydration.

Dysphagia: Esophageal dysmotility and aspiration have been associated with antipsychotic drug use; use caution in patients at risk for aspiration pneumonia.

Concomitant Medication: Decreasing the ARISTADA dosage is recommended in patients taking strong CYP3A4 inhibitors and/or strong CYP2D6 inhibitors for longer than 2 weeks. Increasing the ARISTADA dosage from 441 mg to 662 mg is recommended in patients taking CYP3A4 inducers for longer than 2 weeks. No ARISTADA dosage changes are recommended for patients taking CYP450 modulators for less than 2 weeks.

Most Commonly Observed Adverse Reaction: The most common adverse reaction (≥5% incidence and at least twice the rate of placebo reported by patients treated with ARISTADA 441 mg and 882 mg monthly) was akathisia.

Injection-Site Reactions: Injection-site reactions were reported by 4%, 5%, and 2% of patients treated with 441 mg ARISTADA (monthly), 882 mg ARISTADA (monthly), and placebo, respectively. Most of these were injection-site pain and associated with the first injection and decreased with each subsequent injection. Other injection-site reactions (induration, swelling, and redness) occurred at less than 1%.

Dystonia: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first days of treatment and at low doses.

Pregnancy/Nursing: May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. Advise patients to notify their healthcare provider of a known or suspected pregnancy. Inform patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ARISTADA during pregnancy. Aripiprazole is present in human breast milk. The benefits of breastfeeding should be considered along with the mother’s clinical need for ARISTADA and any potential adverse effects on the infant from ARISTADA or from the underlying maternal condition.

Please see full Prescribing Information, including Boxed Warning.