How to order ARISTADA

Place an order today.

To order ARISTADA, contact your wholesaler/distributor

For ARISTADA® (aripiprazole lauroxil) product information, call 1-866-ARISTADA (1-866-274-7823) or visit aristadahcp.com.

Direct-purchase discounts are available to eligible providers through the Alkermes provider distribution partner, Besse Medical.*

*Contact Besse Medical regarding eligibility for program pricing.

Wholesaler/DistributorAristada NDC No.
441 mg Item #65757-0401-03
662 mg Item #65757-0402-03
882 mg Item #65757-0403-03
1064 mg Item #65757-0404-03
Wholesaler/DistributorAmerisourceBergen®
441 mg Item #10158930
662 mg Item #10158907
882 mg Item #10158906
1064 mg Item #10178590
Wholesaler/DistributorANDA Inc.
441 mg Item #804348
662 mg Item #804349
882 mg Item #804350
1064 mg Item #804531
Wholesaler/DistributorBurlington Drug
441 mg Item #827196
662 mg Item #827188
882 mg Item #827170
1064 mg Item #446559
Wholesaler/DistributorCardinal Health
441 mg Item #5161427
662 mg Item #5161492
882 mg Item #5161567
1064 mg Item #5368352
Wholesaler/DistributorDakota Drug Inc. (DDI)
441 mg Item #262188
662 mg Item #262204
882 mg Item #262212
1064 mg Item #312314
Wholesaler/DistributorHD Smith
441 mg Item #551-7206
662 mg Item #551-7214
882 mg Item #551-7222
1064 mg Item #566-8843
Wholesaler/DistributorKinray
441 mg item #5161427
662 mg item #5161492
882 mg item #5161567
1064 mg item #5368352
Wholesaler/DistributorLouisana Wholesale
441 mg item #166165
662 mg item #166173
882 mg item #166181
1064 mg item #189589
Wholesaler/DistributorMcKesson
441 mg item #3489051
662 mg item #3489069
882 mg item #3489077
1064 mg item #3670726
Wholesaler/DistributorMiami-Luken Inc.
441 mg item #181-750
662 mg item #181-768
882 mg item #181-776
1064 mg item #205-880
Wholesaler/DistributorMorris & Dickson
441 mg item #398776
662 mg item #398834
882 mg item #399311
1064 mg item #981852
Wholesaler/DistributorN.C. Mutual Drug
441 mg item #195024
662 mg item #195032
882 mg item #195040
1064 mg item #270538
Wholesaler/DistributorR&S Northeast
441 mg item #40103
662 mg item #40203
882 mg item #40303
1064 mg item #40403
Wholesaler/DistributorRochester Drug Cooperative (RDC)
441 mg item #10698942
662 mg item #10698959
882 mg item #10698967
1064 mg item #10737922
Wholesaler/DistributorSmith Drug
441 mg item #741918
662 mg item #741900
882 mg item #741926
1064 mg item #809780
Wholesaler/DistributorValue Drug
441 mg item #146044
662 mg item #146048
882 mg item #146046
1064 mg item #175878
ARISTADA Wholesale Order Entry Number
Wholesaler/Distributor441 mg
Item #
662 mg
Item #
882 mg
Item #
1064 mg
Item #
ARISTADA NDC No.65757-0401-0365757-0402-0365757-0403-0365757-0404-03
AmerisourceBergen®10158930101589071015890610178590
ANDA Inc.804348804349804350804531
Burlington Drug827196827188827170446559
Cardinal Health5161427516149251615675368352
Dakota Drug Inc. (DDI)262188262204262212312314
HD Smith551-7206551-7214551-7222566-8843
Kinray5161427516149251615675368352
Louisana Wholesale166165166173166181189589
McKesson3489051348906934890773670726
Miami-Luken Inc.181-750181-768181-776205-880
Morris & Dickson398776398834399311981852
N.C. Mutual Drug195024195032195040270538
R&S Northeast40103402034030340403
Rochester Drug Cooperative (RDC)10698942106989591069896710737922
Smith Drug741918741900741926809780
Value Drug146044146048146046175878
To order samples, talk to your ARISTADA representative. If you don't know your representative, request a visit.

Indication

ARISTADA® (aripiprazole lauroxil) is indicated for the treatment of schizophrenia.

Important Safety Information

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. ARISTADA is not approved for the treatment of patients with dementia-related psychosis.

Contraindication: Known hypersensitivity reaction to aripiprazole. Reactions have ranged from pruritus/urticaria to anaphylaxis.

Cerebrovascular Adverse Reactions, Including Stroke: Increased incidence of cerebrovascular adverse reactions (e.g., stroke, transient ischemic attack), including fatalities, have been reported in placebo-controlled trials of elderly patients with dementia-related psychosis treated with risperidone, aripiprazole, and olanzapine. ARISTADA is not approved for the treatment of patients with dementia-related psychosis.

Neuroleptic Malignant Syndrome (NMS): A potentially fatal symptom complex sometimes referred to as NMS may occur with administration of antipsychotic drugs, including ARISTADA. Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia). Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure. The management of NMS should include: 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy; 2) intensive symptomatic treatment and medical monitoring; and 3) treatment of any concomitant serious medical problems for which specific treatments are available.

Tardive Dyskinesia (TD): The risk of developing TD (a syndrome of abnormal, involuntary movements) and the potential for it to become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic increase. The syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses. Prescribing should be consistent with the need to minimize TD. Discontinue ARISTADA if clinically appropriate. TD may remit, partially or completely, if antipsychotic treatment is withdrawn.

Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that include:

  • Hyperglycemia/Diabetes Mellitus: Hyperglycemia, in some cases extreme and associated with ketoacidosis, coma, or death, has been reported in patients treated with atypical antipsychotics. There have been reports of hyperglycemia in patients treated with oral aripiprazole. Patients with diabetes should be regularly monitored for worsening of glucose control; those with risk factors for diabetes should undergo baseline and periodic fasting blood glucose testing. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia, including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia should also undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients require continuation of antidiabetic treatment despite discontinuation of the suspect drug.
  • Dyslipidemia: Undesirable alterations in lipids have been observed in patients treated with atypical antipsychotics.
  • Weight Gain: Weight gain has been observed with atypical antipsychotic use. Clinical monitoring of weight is recommended.

Pathological Gambling and Other Compulsive Behaviors: Compulsive or uncontrollable urges to gamble have been reported with use of aripiprazole. Other compulsive urges less frequently reported include sexual urges, shopping, binge eating and other impulsive or compulsive behaviors which may result in harm for the patient and others if not recognized. Closely monitor patients and consider dose reduction or stopping ARISTADA if a patient develops such urges.

Orthostatic Hypotension: Aripiprazole may cause orthostatic hypotension which can be associated with dizziness, lightheadedness, and tachycardia. Monitor heart rate and blood pressure, and warn patients with known cardiovascular or cerebrovascular disease and risk of dehydration and syncope.

Falls: Antipsychotics including ARISTADA may cause somnolence, postural hypotension, or motor and sensory instability, which may lead to falls and subsequent injury. Upon initiating treatment and recurrently, complete fall risk assessments as appropriate.

Leukopenia, Neutropenia, and Agranulocytosis: Leukopenia, neutropenia, and agranulocytosis have been reported. Patients with a history of clinically significant low white blood cell count (WBC)/absolute neutrophil count (ANC) and history of drug-induced leukopenia/neutropenia should have frequent complete blood count (CBC) during the first few months of receiving ARISTADA. Consider discontinuation of ARISTADA at the first sign of a clinically significant decline in WBC count in the absence of other causative factors. Monitor patients with clinically significant neutropenia for fever or other symptoms or signs of infection and treat promptly if such symptoms or signs occur. Discontinue ARISTADA in patients with severe neutropenia (absolute neutrophil count <1000/mm3) and follow their WBC until recovery.

Seizures: ARISTADA should be used with caution in patients with a history of seizures or with conditions that lower the seizure threshold.

Potential for Cognitive and Motor Impairment: ARISTADA may impair judgment, thinking, or motor skills. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are certain ARISTADA does not affect them adversely.

Body Temperature Regulation: Disruption of the body’s ability to reduce core body temperature has been attributed to antipsychotic agents. Advise patients regarding appropriate care in avoiding overheating and dehydration. Appropriate care is advised for patients who may exercise strenuously, may be exposed to extreme heat, receive concomitant medication with anticholinergic activity, or are subject to dehydration.

Dysphagia: Esophageal dysmotility and aspiration have been associated with antipsychotic drug use; use caution in patients at risk for aspiration pneumonia.

Concomitant Medication: Decreasing the ARISTADA dosage is recommended in patients taking strong CYP3A4 inhibitors and/or strong CYP2D6 inhibitors for longer than 2 weeks. Increasing the ARISTADA dosage from 441 mg to 662 mg is recommended in patients taking CYP3A4 inducers for longer than 2 weeks. No ARISTADA dosage changes are recommended for patients taking CYP450 modulators for less than 2 weeks.

Most Commonly Observed Adverse Reaction: The most common adverse reaction (≥5% incidence and at least twice the rate of placebo reported by patients treated with ARISTADA 441 mg and 882 mg monthly) was akathisia.

Injection-Site Reactions: Injection-site reactions were reported by 4%, 5%, and 2% of patients treated with 441 mg ARISTADA (monthly), 882 mg ARISTADA (monthly), and placebo, respectively. Most of these were injection-site pain and associated with the first injection and decreased with each subsequent injection. Other injection-site reactions (induration, swelling, and redness) occurred at less than 1%.

Dystonia: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first days of treatment and at low doses.

Pregnancy/Nursing: May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. Advise patients to notify their healthcare provider of a known or suspected pregnancy. Inform patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ARISTADA during pregnancy. Aripiprazole is present in human breast milk. The benefits of breastfeeding should be considered along with the mother’s clinical need for ARISTADA and any potential adverse effects on the infant from ARISTADA or from the underlying maternal condition.

Please see full Prescribing Information, including Boxed Warning.